Structure-function relationship of bifunctional scorpion toxin BmBKTx1

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Gene expression, mutation, and structure-function relationship of scorpion toxin BmP05 active on SK(Ca) channels.

Four peptide inhibitors of small-conductance Ca(2+)-activated, apamin-sensitive K(+) channels (SK(Ca)) have been isolated from the venom of the Chinese scorpion Buthus martensi, named BmP01, BmP02, BmP03, and BmP05, respectively [Romi-Lebrun, R. (1997) Eur. J. Biochem. 245, 457-464]. Among them BmP05 with 31 amino acid residues has been intensively studied due to its most potent toxicity. To in...

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ژورنال

عنوان ژورنال: Acta Biochimica et Biophysica Sinica

سال: 2008

ISSN: 1672-9145,1745-7270

DOI: 10.1111/j.1745-7270.2008.00479.x